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Updated: Jun 20, 2025

Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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在GRAIL1中,GRAIL1通过Ubiquitin Ligase独立的伴侣调节功能稳定了错误折叠的突变p53

Paramita Ray1, Sangeeta Jaiswal2, Daysha Ferrer-Torres2

  • 1Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.

Molecular cancer research : MCR
|July 17, 2024
PubMed
概括

研究人员发现了一种降解突变p53的新方法,这是一种驱动食道癌的蛋白质. 一种新针对热冲击蛋白40/DNAJ,抑制其伴侣活性以减少癌细胞存活率.

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