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Updated: Jun 20, 2025

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
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人类pyruvate脱酶复合物的固体测量和结构

Rafal Zdanowicz1, Pavel Afanasyev2, Adam Pruška3

  • 1Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Otto-Stern-Weg 5, 8093 Zürich, Switzerland.

Science advances
|July 17, 2024
PubMed
概括

阐明了人体酸盐脱酶复合体 (PDHc) 核心结构,揭示了48个二利胺酸乙烯转移酶 (E2) 子单元和12个二利胺酸脱酶结合蛋白 (E3BP) 子单元. 这种详细的结构解释了PDHc如何达到最大的酶活性.

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