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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
强大的,可扩展的,高度选择性的螺旋环催化剂用于工业化水合成型和异构化-水合成型
Yan Zong1, Runtong Zhang2, Baode Ma1,2
1Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China.
新的螺旋环二酸盐配体,特别是O-SDPhite,显著增强水合形成 (HF) 和异构化-水合形成 (ISO-HF) 反应. 这些催化剂为化物生产提供了卓越的活性,选择性和稳定性,改善了工业过程.
科学领域:
- 催化剂是一种催化剂.
- 有机化学 有机化学
- 工业化学 工业化学 工业化学
背景情况:
- 甲基化 (HF) 和异构化-甲基化 (ISO-HF) 是化合成的关键工业过程.
- 现有的方法存在低活性,低区域选择性 (线性/分支比) 和有限的催化剂稳定性.
- 开发高效和稳定的催化剂对于优化化物生产至关重要.
研究的目的:
- 开发新的螺旋环二酸盐配体,以克服HF和ISO-HF的局限性.
- 评估这些配体在活性,区域选择性和稳定性方面的催化性能.
- 为了证明这些配体在从工业原料中合成有价值的化物中的应用.
主要方法:
- 合成和表征一种新的类型的螺旋环二酸盐连接体.
- 测试用各种烯酸和C4精炼剂在水合成型和异构化-水合成型反应中的配体.
- 对催化性能与基准配体 (如Biphephos) 的比较分析.
- 在连续运行下进行长期稳定性研究.
主要成果:
- 该O-SDPhite配体在olefins的HF中表现出极好的催化活性和区域选择性.
- 实现了卓越的线性/分支 (l/b) 比例,营业额达到了17620,000.
- O-SDPhite 证明对区域选择性 ISO-HF 的 C4 炼油品到 n-valeraldehyde 有效.
- 连续运行41天,平均l/b比为38.6,超过了Biphephos.
结论:
- 螺旋环二酸盐,特别是O-SDPhite,代表了水合成型催化学的重大进步.
- 这些配体为高效和高度选择性的工业化物合成提供了有前途的解决方案.
- 改进的稳定性和性能为更可持续和更经济的化学生产铺平了道路.
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