与植物性饮食相关的血蛋白:来自社区动脉样硬化风险 (ARIC) 研究和弗雷明汉心脏研究 (FHS) 的结果
Hyunju Kim1, Jingsha Chen2, Brenton Prescott3
1Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington School of Public Health, Seattle, WA, USA.
Clinical nutrition (Edinburgh, Scotland)
|July 17, 2024
概括
这项研究确定了各种植物性饮食 (PDI) 和健康植物性饮食 (hPDI) 的血蛋白生物标志物. 这些生物标志物可能有助于解释植物性饮食如何影响慢性疾病风险.
科学领域:
- 营养蛋白质组学 营养蛋白质组学
- 生物标志物发现发现
- 慢性疾病流行病学 慢性疾病流行病学
背景情况:
- 植物性饮食与降低慢性疾病风险有关.
- 大规模蛋白质组学可以识别饮食生物标志物.
- 了解饮食健康路径至关重要.
研究的目的:
- 研究血蛋白质组与四种植物性饮食 (PDI,素食主义者,hPDI,UPDI) 的关联.
- 确定植物性饮食的客观生物标志物.
- 在独立的队列中复制发现.
主要方法:
- 使用了ARIC和FHS队列的蛋白质组学和食品频率问卷数据.
- 采用多变量线性回归和内部/外部复制.
- 执行过度代表路径和C统计分析.
主要成果:
- 在ARIC发现中确定了837种饮食蛋白协会,其中453种内部复制.
- 在FHS.中,有8种蛋白 (8种HPDI) 在外部复制.
- 已确定的途径包括补充/凝血,细胞粘附和视网醇代谢.
结论:
- 发现了植物性饮食的候选蛋白质生物标志物.
- 确定了将植物性饮食与健康结果联系起来的潜在途径.
- 蛋白质组的洞察力可以促进对饮食相关慢性疾病的理解.
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