除了肺癌:空气污染和膀,乳腺和前列腺癌的发病率
Inass Kayyal-Tarabeia1,2, Aviad Zick3,4, Itai Kloog5
1The Health & Environment Research (HER) Lab, Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
International journal of epidemiology
|July 17, 2024
概括
空气污染,特别是细颗粒物 (PM2.5),与癌症风险增加有关,包括肺癌,膀癌,乳腺癌和前列腺癌. 减少空气污染暴露的政策至关重要.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 空气污染是已知的致癌物,特别是肺癌.
- 现有的研究表明,关于空气污染对其他癌症类型的影响,存在知识差距和混合的发现.
研究的目的:
- 调查环境空气污染,包括细颗粒物 (PM2.5) 和氧化 (NOx) 与癌症发病率之间的联系.
- 评估各种癌症的风险,与暴露于PM2.5和NOx有关.
主要方法:
- 利用历史地址数据进行超过90万名参与者的暴露评估.
- 分析了2007年至2015年的原发性癌症诊断 (30,979例).
- 采用考克斯回归模型来确定与空气污染物相关的癌症风险的危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- PM2.5的四分位数间范围增加与所有癌症部位 (HR=1.51),肺癌 (HR=1.73),膀癌 (HR=1.50),乳腺癌 (HR=1.50) 和前列腺癌 (HR=1.41) 的更高风险有关.
- 在单一污染物和共同污染物模型中,PM2.5在所有研究的癌症部位中与NOx相比,与癌症发病率有更强烈的关联.
结论:
- 这些发现证实了环境空气污染对肺癌的致癌性.
- 提供证据,将空气污染与膀,乳腺和前列腺癌的风险增加联系起来.
- 敦促实施政策,减少人口对空气污染的暴露,尽管正在进行的前列腺癌确认研究需要.
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