在治疗耐药双极性抑郁症中短期服用胺时出现治疗症状:一项回顾性横截面描述性研究
Michał Pastuszak1, Wiesław Jerzy Cubała1, Aleksander Kwaśny1
1Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Gdańsk 80-214, Poland.
Asian journal of psychiatry
|July 17, 2024
概括
治疗双极性抑郁症的静脉胺可能会导致治疗出现的症状,如食欲变化和高睡眠症. 需要进一步的研究来理解这些影响,并为治疗出现的症状 (TES) 建立明确的定义.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 对双极性抑郁症的药物治疗通常会导致出现症状,需要仔细监测.
- 治疗耐药双极性抑郁症 (TRBD) 在治疗期间管理新出现的症状时存在独特的挑战.
研究的目的:
- 在TRBD患者中调查八次静脉注射胺和治疗出现的抑郁症状 (TES) 之间的相关性.
- 确定在继续基线精神药物和体疗法的患者中,在胺治疗期间出现的特定TES.
主要方法:
- 观察性研究设计.观察性研究设计.
- 使用抑郁症症状自报告30 (IDS-SR30) 库存评估抑郁症状.
- 定义TES是指在基线时缺少但在治疗后存在的症状.
主要成果:
- 常见的TES包括食欲下降,体重增加,高睡眠症和白天情绪变化.
- 在所有患者中,没有悲伤,改变未来感知,降低性欲和身体不适等特定症状.
- 13.6%的患者在治疗期间报告了自杀想法.
结论:
- 对TRBD的静脉胺与特定的TES有关,包括食欲和睡眠障碍.
- 具有综合结果测量的更大规模研究对于全面了解TES至关重要.
- 为了提高未来的研究质量,需要对TES的标准化定义.
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