在卵巢切除的老鼠中具有抗骨质疏松功效的Farnesyl pyrophosphate合成酶抑制剂:一种混合结合的方法超出了双酸盐

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Naglaa F El-Sayed1, Marwa El-Hussieny1, Shaimaa T Mansour1

  • 1Organometallic and Organometalloid Chemistry Department, National Research Centre, 33 ElBohouth St., (Former El Tahrir) Dokki, P.O. 12622, Giza, Egypt.

European journal of medicinal chemistry
|July 17, 2024
PubMed
概括

研究人员开发了新的非双酸盐化合物,其向人体法纳西酸盐合成酶 (hFPPS). 化合物4a表现出显著的hFPPS抑制和抗吸收特性,显示出对骨质疏松症治疗的潜力.

关键词:
抗骨质疏松症的治疗方法这是一种Farnesyl酸盐合成酶抑制剂.没有双酸盐的非双酸盐在卵巢切除的老鼠身上.瓦尼林是一种佐勒多酸盐是一种酸盐.

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