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乳杆菌帕拉凯西亚种. 帕拉凯西NTU 101通过调节肥胖大鼠的AMPK通路和肠道微生物群来预防肥胖

SukJin Kim¹, Gwi Hwan Na¹, Dong Joon Yim¹

¹Department of R&I Center, COSMAXBIO, Seongnam, 13486, South Korea.

Biochemical and biophysical research communications

|July 17, 2024

概括

乳酸菌类菌 NTU 101 (NTU 101) 通过减少脂肪积累和体重,显示出显著的抗肥胖作用. 这种益生菌还积极影响肠道微生物群,并增强脂肪酸氧化.

科学领域:

微生物学微生物学
营养科学营养科学
生物化学生物化学

背景情况:

肥胖是一种复杂的代谢障碍,对健康有重大影响.
益生菌越来越多地被研究其在体重管理中的潜在作用.
乳杆菌帕拉凯西亚种. paracasei NTU 101 (NTU 101) 是一种具有潜在健康益处的特定细菌菌株.

研究的目的:

为了在体外和体内评估Lactobacillus paracasei NTU 101 (NTU 101) 的抗肥胖作用.
调查NTU 101对脂肪代谢和脂肪生成的影响背后的分子机制.
评估NTU 101对肠道微生物群组成的影响.

主要方法:

使用3T3-L1细胞进行体外研究,通过MTT和Oil Red O测定来评估细胞毒性和脂质积累抑制.
使用高脂肪饮食诱导的肥胖大鼠进行体内研究,以评估抗肥胖作用.
西方涂抹分析与肥胖,脂肪酸氧化和脂肪生成相关的蛋白质表达 (PPARα,PPARγ,C/EBPα,p-AMPK,CPT-1).
肠道微生物群分析以确定细菌组成的变化.

主要成果:

在3T3-L1脂肪细胞中,NTU 101显著减少了50%以上的脂质积累.
在肥胖大鼠中,口服NTU 101减弱了体重增加和脂肪组织体重.
通过增加肝脏中的PPARα,CPT-1和p-AMPK表达,NTU 101增强了脂肪酸氧化.
通过降低脂肪组织中的PPARγ和C/EBPα表达,NTU 101抑制了脂肪生成.
补充NTU 101调节了肠道微生物群,显著增加了Akkermansiaceae的丰富性.

结论:

乳杆菌虫 (Lactobacillus paracasei NTU 101) 具有显著的抗肥胖特性.
NTU 101通过调节肠道微生物群,增强脂肪酸氧化和抑制脂肪生成而起作用.
这项研究支持NTU 101作为治疗肥胖的益生菌干预措施的潜力.

关键词:

增脂生殖是一种增脂的过程.脂肪氧化过程中的脂肪氧化.牛乳杆菌帕拉凯西 (Lactobacillus paracasei) 是一种美国国家工业联合会NTU 101 肥胖问题肥胖问题益生菌益生菌益生菌

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