社会经济地位与结构性脑损伤以及连接性和认知功能之间的关联:马斯特里赫特研究
Anouk F J Geraets1, Miranda T Schram2, Jacobus F A Jansen3
1Department of Social Sciences, University of Luxembourg, Esch-Sur-Alzette, Luxembourg.
Social science & medicine (1982)
|July 17, 2024
概括
社会经济地位 (SEP) 显著影响认知功能,以后的生活SEP调解了这种影响. 结构性脑损伤和连接性在这种关联中起到较小的作用.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 老年学是指老年学的学科.
背景情况:
- 社会经济不平等与认知障碍有关,可能是通过大脑结构和连接.
- 了解将社会经济地位 (SEP) 与认知功能联系在一起的途径对于公共卫生干预至关重要.
研究的目的:
- 调查晚年SEP在早期SEP和晚年认知功能之间的关联中扮演的调解角色.
- 为了确定结构性脑损伤和连接性是否解释了SEP和认知功能之间的关系.
主要方法:
- 马斯特里赫特研究的横截面分析 (n=4,839).
- 评估生命早期和生命后期的SEP指标.
- 认知测试和3-T MRI用于大脑结构 (白质高强度,灰质,白质,脑脊液) 和结构连接.
- 多重线性回归和结构方程建模用于调解分析.
主要成果:
- 晚年SEP解释了早期SEP与晚年认知功能之间的关联的很大一部分 (72.2%) .
- 结构性脑损伤和连接性显示SEP和认知功能之间的小调解效应 (高达5.9%).
- 在晚年认知功能中观察到显著的社会经济差异.
结论:
- 晚年社会经济地位是认知功能的主要决定因素,调解了早期社会经济地位的影响.
- 大脑结构损伤和连接性在解释认知功能的社会经济梯度方面发挥着有限的作用.
- 针对社会经济因素的干预措施可能是减少认知不平等的关键.
更多相关视频
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
14.9K
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
15.1K
相关概念视频
Language and Cognition
340
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
340
Biological Influences on Intelligence
86
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
86
Brain Imaging
224
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
224
Association Areas of the Cortex
5.2K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.2K
Role of Cerebellum and Prefrontal Cortex in Memory
409
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
409
