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产前父母对金属和出生缺陷的暴露:一个潜在的出生队列研究

Hong Lv^1,2,3, Yangqian Jiang^1,4, Kan Ye⁵

¹State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China.

Environmental science & technology

|July 17, 2024

概括

怀孕期间父亲和母亲接触金属会增加出生缺陷的风险. 建议基于夫妇的预防策略来减少后代的这些风险.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
儿科儿科儿科

背景情况:

母亲对金属的暴露是已知的出生缺陷的风险因素.
父亲接触金属对后代发育的影响不太清楚.

研究的目的:

调查产前父亲和母亲的金属暴露,以及父母的共同暴露,与单独生儿出生缺陷的风险之间的联系.

主要方法:

从江苏出生队伍中招募了1675个父子三人组.
在怀孕早期,测量了父母25种金属的尿度.
分析了金属暴露与出生缺陷患病率在1岁以下之间的关联.

主要成果:

父亲接触,,,,,,,,,铜和,以及母亲接触,,,铜,和,与出生缺陷风险增加有关.
这些关联在调整为父母共同暴露后仍然显著.
在混合物分析中,父亲和母亲的暴露显示出最高的相对重要性.
父母对金属混合物的共同暴露表明,对整体和特定的出生缺陷亚型有显著的联合作用.

结论:

父亲和母亲对金属的暴露都会导致出生缺陷的风险.
一个全面的,以夫妇为基础的方法来管理金属暴露对于预防出生缺陷至关重要.

关键词:

出生的队列队列出生.出生缺陷是一种出生缺陷.母亲暴露的母亲暴露.金属的金属的金属.父母暴露的父母暴露.父亲暴露的父亲暴露.

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