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Updated: Jun 20, 2025

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy
06:38

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy

Published on: February 7, 2019

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对影响先驱因子结合特性的序列特征的系统剖析揭示了FOXA1和AP-1之间的结合协同作用

Cheng Xu1, Holly Kleinschmidt1, Jianyu Yang1

  • 1Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA; Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park, PA 16802, USA.

Molecular cell
|July 17, 2024
PubMed
概括

像FOXA1这样的先驱因子结合了特定的DNA序列,受到其他转录因子和局部DNA特征的影响,而不仅仅是染色质状态. 这项研究澄清了先驱因子结合特异性的规则.

关键词:
在 ChIP-ISO 中使用.具有约束力的合作性.具有约束性的特异性.在这种情况下,染色染色素开拓者因素是开拓者因素.合成DNA库是一个合成DNA库.转录因子的转录因子

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