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黑胡卜塑造了肠道微生物群的形状,并通过肠骨轴降低了绝经后骨质疏松症的风险:来自试点随机对照试验的证据
Briana M Nosal1, Staci N Thornton2, Manije Darooghegi Mofrad1
1Department of Nutritional Sciences, University of Connecticut, Storrs, CT.
六个月的黑胡卜 (BC) 补充剂有助于维持绝经后妇女的骨矿物质密度 (BMD). 这种益处可能源于BC对肠道细菌的积极影响和减少炎症标志物,这表明肠道健康和骨保护之间存在联系.
科学领域:
- 营养科学 营养科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 更年期与骨质损失和骨质疏松症风险增加有关.
- 肠道微生物群的改变和慢性炎症与骨代谢有关.
- 黑胡卜 (BC) 含有丰富的反素,可能具有抗炎性质.
研究的目的:
- 研究黑胡卜 (BC) 补充剂对骨矿物质密度 (BMD) 的影响.
- 检查BC对肠道微生物群组成和炎症/免疫反应的影响.
- 探索肠道微生物群,炎症和骨质变化之间的关系.
主要方法:
- 试点随机,双盲,安慰剂对照试验,涉及51名近期和早期绝经后妇女 (年龄45-60岁).
- 参与者接受了安慰剂,低BC (392毫克/天) 或高BC (784毫克/天) 6个月.
- 评估包括DXA扫描BMD,便分析肠道微生物群,以及血液检测炎症生物标志物 (例如IL-1β,RANKL).
主要成果:
- 六个月的BC补充剂显著减轻了全身骨矿物质密度 (BMD) 损失 (P<.05).
- 高BC摄入量显示出降低外围IL-1β和RANKL水平的趋势.
- BC补充剂剂量取决于增加了Ruminococcus 2的丰富度,这是一种与骨质量变化相关的肠道细菌.
结论:
- 6个月每天食用黑胡卜有助于在绝经后妇女中保持骨质.
- 通过调节肠道微生物群和减少骨质结核性细胞因子,BC可能会产生骨保护作用.
- 需要进一步研究BC的益处以及Ruminococcus 2在骨健康中的作用.
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