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衰老调节了饮食葡萄糖指数对小鼠肠道微生物群组成的影响

Ying Zhu¹, Emily N Yeo², Kelsey M Smith¹

¹JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States; Division of Biochemical and Molecular Nutrition, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States.

The Journal of nutrition

|July 17, 2024

概括

老龄化和饮食显著改变肠道微生物群的组成,特定的细菌种群对这两种因素都有反应. 这些变化可能会影响与年龄有关的疾病.

科学领域:

微生物学微生物学
老年学是一门学科.
营养科学营养科学

背景情况:

肠道微生物组的组成影响宿主生理学,并由饮食和寿命调节.
对肠道微生物群的饮食与衰老相互作用尚未得到充分理解.
以前的研究表明,糖分指数饮食会改变小鼠的肠道微生物群.

研究的目的:

检查衰老对饮食引起的肠道微生物群变化的作用.
确定对饮食和衰老有反应的肠道细菌种群.

主要方法:

研究年轻,中年和老年雄性小鼠,食高血糖 (HG) 或低血糖 (LG) 饮食.
使用16S rDNA元基因组测序分析了便微生物组合.
评估了α-多样性,β-多样性和细菌种群丰度的变化.

主要成果:

年轻小鼠表现出较低的α-多样性,但更大的饮食诱导的β-多样性转移.
老老鼠的α-多样性较低,比中年老鼠的β-多样性更高.
随着年龄的增长和HG饮食而增加的Lachnospiraceae;随着LG饮食而增加的Bacteroides_H;随着年龄的增长而减少的Akkermansia muciniphila.

结论:

饮食和衰老在塑造肠道微生物群方面具有复杂的相互作用.
特定的细菌种群对衰老和饮食干预都有反应.
这些微生物群的变化可能导致与年龄相关的疾病.

关键词:

衰老的衰老衰老的衰老饮食饮食饮食饮食葡萄糖指数 (Glycemic Index) 是一个指数.微生物组是一个微生物组.抗粉耐药性粉的方法

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