甲基利米达离子液体 - 一种具有内分泌干扰潜力的新类永恒化学物质
Tarek M Abdelghany1, Shireen Hedya2, Alex Charlton3
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt; The Institute of Education in Healthcare and Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresthill, Aberdeen, AB25 2ZD, United Kingdom.
被认为是"绿色"溶剂的甲基胺离子液 (MIL) 显示出潜在的环境和人类健康风险. 短链MIL激活雌激素受体并具有雌激素作用,而长链MIL则降解为潜在的危险代谢物.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 绿色化学 绿色化学
背景情况:
- 甲基利米达离子液体 (MILs) 被提议作为可持续的.
- 绿色 绿色 绿色 绿色 绿色
- 工业应用的溶剂,如生物燃料生产.
- 然而,它们的环境持久性和潜在毒性,特别是内分泌干扰,仍然基本上没有特征.
- 一个特定的MIL,1-octyl-3-methylimidazolium (M8OI),已经证明了人类雌激素受体α (ERα) 的激活.
研究的目的:
- 为了评估不同链长度的各种甲基利米达离子液体 (MILs) 的环境稳定性和人类毒性.
- 为了研究MILs在活体和体外激活人类雌激素受体α (ERα) 的潜力.
- 评估河水中的MILs的代谢命运和人类肝脏模型系统.
主要方法:
- 在河水和人类肝脏模型中测试甲基利米达 (MI) 和各种链长度MIL (2C-10C) 的稳定性.
- 在MILs体外查人类ERα激活.
- 在体内评估前青春期大鼠的雌激素活性.
- 基于结构的MIL结合ERα的计算分析.
主要成果:
- 短链MIL (EMI,BMI,HMI) 在河水和人类肝脏模型中呈现微不足道的退化.
- 短链MILs在体外激活了人体ERα,并在体内证明了雌激素作用.
- 计算机建模预测短链MILs与ERα的雌激素位点和一个额外的位点结合.
- 长链MIL (M8OI,DMI) 在河水中进行了部分代谢和矿化.
- 长链MILs的代谢物可能会构成持续的危险.
结论:
- 短链MIL具有内分泌干扰的潜力,激活ERα并表现出雌激素性.
- MILs,特别是短链变种,可能会在环境中持续存在,并对人类和动物健康构成风险.
- 对于MIL成为MIL的潜力.
- 永远的化学品 永远的化学品
- 需要进一步研究它们的长期环境影响和毒理特征.
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