长期暴露于空气污染和肺移植后初级移植功能障碍的风险
Tatsuki Koyama1, Zhiguo Zhao1, John R Balmes2
1Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
概括
长期暴露于空气污染物并没有显著增加肺移植后初级移植功能障碍 (PGD) 的风险. 这项研究表明,其他因素与肺移植接受者的PGD发展有更强烈的联系.
科学领域:
- 肺部医学 肺部医学
- 移植免疫学 移植免疫学
- 环境健康 环境健康
背景情况:
- 主要移植功能障碍 (PGD) 是肺移植后死亡的主要原因.
- 对于PGD的潜在机制的理解尚不完全.
- 以前的研究将空气污染物暴露与肺移植候选人的不良结果和慢性肺异位移植功能障碍联系起来.
研究的目的:
- 调查长期暴露于环境空气污染物和肺移植接受者的PGD风险之间的关联.
- 为了确定肺捐赠者或接受者暴露于臭氧,NO2,SO2,CO,PM2.5和PM10等污染物是否会影响PGD的发展.
主要方法:
- 利用了来自肺移植结果组队列的1428名肺移植接受者及其捐赠者的数据.
- 评估了基于邮政编码的估计,对捐赠者和接受者的六种主要空气污染物的长期暴露.
- 采用单变量和多变量模型,控制已知的PGD风险因素.
主要成果:
- 没有发现供体或受体空气污染物暴露与PGD发病率之间存在显著的关联.
- 该研究没有在这个队列中确定环境空气污染水平与PGD风险之间的联系.
结论:
- 环境空气污染物的暴露,在研究的水平上,可能不是PGD发展的主要驱动因素.
- 已确定的PGD风险因素似乎与PGD的关联比检查的空气污染物更为强大.
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