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经PEG修饰的Fe₂O₃涂层的阿加水凝:一种合成的纳米复合材料,用于调节的5-甲输送

Mehrab Pourmadadi¹, Negar Abbaszade Garousi², Majid Abdouss²

¹Protein Research Center, Shahid Beheshti University, GC, Tehran 1983963113, Iran.

International journal of biological macromolecules

|July 17, 2024

概括

一种新型的pH响应纳米复合物,PEG-AGA-Fe2O3@5-Fu,精确地将5-甲 (5-Fu) 传递给乳腺癌细胞. 这种先进的纳米技术显示了改善癌症治疗的希望,并证明了生物相容性.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

乳腺癌仍然是导致死亡的主要原因,需要先进的药物输送系统.
目前的疗法在向性治疗和最大限度地减少全身毒性方面面临挑战.
纳米技术为提高治疗效率和减少副作用提供了潜在的解决方案.

研究的目的:

开发和描述一种新型的pH响应纳米复合材料,用于向的5-甲 (5-Fu) 输送.
评估纳米复合材料的物理化学特性和体外药物释放特征.
评估纳米复合材料用于乳腺癌治疗的生物相容性.

主要方法:

一种用聚乙烯糖醇 (PEG) 修改的亚甘 (AGA) 水凝,涂上氧化铁 (Fe2O3) 纳米颗粒的合成.
使用双重乳液技术与杏仁油和Span 80用于纳米复合材料的形成和缩小尺寸.
使用FT-IR,XRD,FE-SEM,VSM,DLS和泽塔电位测量的表征.

主要成果:

成功合成了PEG-AGA-Fe2O3@5-Fu纳米复合材料,平均粒子大小为223nm,泽塔电位为-47.6mV.
FE-SEM和VSM证实了粒子分布均.
在pH 5.4和pH 7.4.4时,已被证明是依赖pH的,在体外调节的5-Fu释放.
显示生物相容性,没有观察到对瘤细胞的有害影响.

结论:

开发的pH响应纳米复合物 (PEG-AGA-Fe2O3@5-Fu) 是针对乳腺癌治疗中向5-甲的有希望的平台.
纳米复合材料的受控释放和生物相容性突显了其作为癌症治疗纳米医学进步的潜力.
对体内疗效的进一步研究是有必要的,以将这种纳米技术转化为临床应用.

关键词:

5-甲 (5-Fu) 是一种甲.亚加洛斯水凝是一种水凝.乳腺癌乳腺癌乳腺癌药物交付是药物交付的过程.(Fe) 是一种 (Fe) 化合物.聚乙烯糖醇是一种聚乙烯糖醇.持续释放的释放是一种持续释放.响应pH的纳米复合材料

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