肝硬度测量的动态和初级胆管胆道炎的临床过程
Laurent Lam1, Pierre-Antoine Soret2, Sara Lemoinne2
1Sorbonne University, Inserm, Pierre Louis Institute of Epidemiology and Public Health, Paris; Public Health Unit, Saint-Antoine Hospital, Assistance Publique - Hôpitaux de Paris, European Reference Network on Hepatological Diseases (ERN Rare-Liver), Paris, France.
概括
随着时间的推移,追踪一次性胆道胆道炎 (PBC) 的肝硬度显著预测了严重的临床事件. 肝硬度测量 (LSM) 的变化为PBC患者提供了强大的预后工具.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 在初级胆道胆道炎 (PBC) 中静态肝硬度测量 (LSM) 已经确定了预后价值.
- 在PBC中LSM时间过程的预后贡献仍然不清楚.
研究的目的:
- 调查一次性胆道胆炎 (PBC) 患者纵向肝硬度测量 (LSM) 变化增加的预后价值.
- 量化LSM轨迹与严重临床事件 (SCE) 风险之间的关联.
主要方法:
- 在3078名用ursodeoxycholic acid治疗的PBC患者的国际回顾性队列研究.
- 在2003年至2022年间用于LSM测量的振动控制过时弹性学.
- 应用联合建模来评估LSM轨迹和SCE发病率之间的关联.
主要成果:
- 总共分析了6362名LSM; 59%的患者显示LSM进展.
- 在LSM的任何相对变化与SCE风险的变化显著相关 (P <.001).
- 增加的LSM与较高的SCE风险相关 (aHR 2.13),而减少的LSM与较低的风险相关 (aHR 0.40).
结论:
- 通过振动控制的短暂弹性图谱进行纵向LSM跟踪,为PBC提供了有价值的预后见解.
- LSM轨迹是PBC中严重临床事件 (SCE) 的强有力的预测指标.
- 在PBC临床试验中,LSM可以作为临床相关的代用终点.
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