新生儿PRICO闭环氧和准系统的性能和安全性:实用多中心交叉研究 (TarOx研究)
Maria Wilinska1,2, Thomas Bachman3, Tomasz Szczapa4,5
1Department of Obstetrics and Perinatology, National Medical Institute, Warsaw, Poland wilinska.maria@gmail.com.
PRICO自动化氧气控制系统改善了婴儿的氧和 (SpO2) 维护,增加了目标正常血范围内的时间. 这种系统有效地降低了高血,而不会增加低血.
科学领域:
- 新生儿重症监护室新生儿重症监护室
- 呼吸辅助系统 呼吸辅助系统
- 自动化生理控制自动化生理控制
背景情况:
- 保持最佳的氧化对早产婴儿至关重要.
- 手动控制吸入氧气 (FiO2) 的分量可以导致低于最佳的SpO2水平.
- 自动化系统旨在提高氧化稳定性.
研究的目的:
- 为了评估法比安预测智能氧化控制 (PRICO) 系统的性能.
- 评估PRICO系统能够自动控制吸入氧气 (FiO2) 分数的能力.
- 为了比较新生儿重症监护中的自动与手动FiO2控制.
主要方法:
- 多中心随机交叉研究涉及39名婴儿.
- 自动 (PRICO) 和手动FiO2控制的24小时周期的比较.
- 主要终点:正常血时间 (90% - 95% SpO2). 二级终点:低血 (<80%) 和高血 (>98%).
主要成果:
- 自动控制显著增加了正常血症的时间 (74%与51%相比).
- 普利科降低了高血的时间 (16%与35%) 和严重的高血 (1%与5%).
- 暴露于严重的低氧化症是低的,在各组之间是相似的.
结论:
- 普里科系统有效地改善了新生儿的SpO2维持.
- 自动化氧气控制可增强正常血,降低高血风险.
- 在新生儿重症监护中,PRICO为更安全的氧气管理提供了一种有前途的方法.
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