在尼古丁依赖的电子烟使用者中改变了岛内功能活动
Yunkai Sun1, An Xie2, Yehong Fang1
1Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China.
Translational psychiatry
|July 17, 2024
概括
尼古丁依赖者使用电子烟会改变成相关区域的大脑活动和连接. 这些变化可以通过静止状态fMRI检测到,可以帮助区分用户与非用户.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 成 药物 药物 药物 药物
背景情况:
- 电子烟 (e-cig) 的使用增加,特别是在年轻人中,引发了人们对长期神经效应的担忧.
- 关于电子烟使用对大脑功能活动的影响的了解有限,特别是在尼古丁依赖的人群中.
研究的目的:
- 研究电子烟使用对尼古丁依赖个体大脑功能活动的长期影响.
- 分析与成相关的大脑区域局部同步 (ReHo) 和功能连接 (FC) 的变化.
主要方法:
- 获取了93名尼古丁依赖电子烟使用者和103名健康对照者的休息状态功能磁共振成像 (rs-fMRI) 数据.
- 在VOXEL级别分析了区域同质性 (ReHo),并在ROI级别分析了核 (NAcc),腹膜区域 (VTA) 和胰岛之间的功能连接 (FC).
- 采用支持矢量机 (SVM) 分类模型,根据rs-fMRI测量区分电子烟用户和HC.
主要成果:
- 与HC相比,电子烟使用者表现出与HC相比,右侧罗兰地克部和右侧胰岛的ReHo增加.
- 在电子烟用户中观察到NAcc,VTA和insula之间的异常FC.
- 在左NAcc中的ReHo与使用电子烟的持续时间之间发现了负相关性.
- 该SVM模型精确地区分了慢性电子烟使用者和HC,准确度为73.47%,AUC为0.781,敏感度为67.74%,特异性为78.64%.
结论:
- 尼古丁依赖的电子烟使用者在与成相关的区域显示失调的自发大脑活动和功能连接.
- 这些发现为制定电子烟使用预防和戒烟干预策略提供了关键的见解.
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