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相关概念视频

Nucleophilic Aromatic Substitution: Elimination–Addition01:11

Nucleophilic Aromatic Substitution: Elimination–Addition

4.0K
Simple aryl halides do not react with nucleophiles. However, nucleophilic aromatic substitutions can be forced under certain conditions, such as high temperatures or strong bases. The mechanism of substitution under such conditions involves the highly unstable and reactive benzyne intermediate. Benzyne contains equivalent carbon centers at both ends of the triple bond, each of which is equally susceptible to nucleophilic attack. This 50–50 distribution of products is...
4.0K
Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)01:30

Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)

3.8K
Nucleophilic substitution in aromatic compounds is feasible in substrates bearing strong electron-withdrawing substituents positioned ortho or para to the leaving group. The reaction proceeds via two steps: the addition of the nucleophile and the elimination of the leaving group.
The reaction begins with an attack of the nucleophile on the carbon that holds the leaving group. This results in the delocalization of the π electrons over the ring carbons. The resonance interaction between...
3.8K
Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation02:24

Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation

7.7K
Introduction
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
7.7K
Preparation of Alkynes: Alkylation Reaction02:27

Preparation of Alkynes: Alkylation Reaction

10.1K
Introduction
Alkylation of terminal alkynes with primary alkyl halides in the presence of a strong base like sodium amide is one of the common methods for the synthesis of longer carbon-chain alkynes. For example, treatment of 1-propyne with sodium amide followed by reaction with ethyl bromide yields 2-pentyne.
10.1K
Electrophilic Aromatic Substitution: Nitration of Benzene01:20

Electrophilic Aromatic Substitution: Nitration of Benzene

5.9K
The nitration of benzene is an example of an electrophilic aromatic substitution reaction. It involves the formation of a very powerful electrophile, the nitronium ion, which is linear in shape. The reaction occurs through the interaction of two strong acids, sulfuric and nitric acid.
5.9K
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN101:14

Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1

2.1K
Treating arylamines with nitrous acid gives aryldiazonium salts that are effective substrates in nucleophilic aromatic substitution reactions. The diazonio group in these salts can be easily displaced by different nucleophiles, yielding a wide variety of substituted benzenes. The leaving group departs as nitrogen gas, and this easy elimination is the driving force for the substitution reaction.
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
2.1K

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Updated: Jun 20, 2025

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
07:30

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

8.1K

选择性地将插入到基中.

Zheng Zhang1, Qi Li1, Zengrui Cheng2

  • 1Department of Chemistry, Institute of Molecular Plus, Tianjin Key Laboratory of Molecular Optoelectronic Science, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.

Nature communications
|July 17, 2024
PubMed
概括
此摘要是机器生成的。

这项研究引入了一种新的分子编辑策略,用于合成含化合物. 该方法有效地将插入基中,使得能够创建有价值的制药中间体和药物修饰.

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Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
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科学领域:

  • 有机化学 有机化学
  • 合成化学 合成化学
  • 药用化学 医学化学

背景情况:

  • 含的化合物在药品和天然产品中至关重要.
  • 现有的合成路线通常涉及多个步骤,导致效率低.
  • 合成替代胺和N-异环的高效方法非常受欢迎.

研究的目的:

  • 开发一种分子编辑策略,以高效地将插入烯中.
  • 为合成各种含化合物提供一个简单的途径.
  • 证明这种方法在制备生物活性分子和修改药物结构方面的实用性.

主要方法:

  • 利用基作为插入的起始材料.
  • 作为源,使用了O-tosiylhydroxylamine的衍生物.
  • 通过对照实验,通过对照实验,研究了一种可能的反应机制,涉及碳酸和胺酸中间体.

主要成果:

  • 在基的Csp2-Csp3键中实现精确的插入.
  • 证明了该方法在高效率合成含化合物的适用性.
  • 成功制备生物活性分子并修改现有的药物支架.

结论:

  • 开发的分子编辑策略为合提供了一个巧妙而高效的途径.
  • 这种方法显著推进了合成化学,制药研究和材料科学.
  • 拟议的机制为反应的基本转换提供了洞察力.