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Updated: Jun 20, 2025

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
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需要DHX9 SUMOylation来抑制R循环相关的基因组不稳定性

Bing-Ze Yang1, Mei-Yin Liu1, Kuan-Lin Chiu2

  • 1Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, 100233, Taiwan.

Nature communications
|July 17, 2024
PubMed
概括

在 lysine 120 处对 RNA 螺旋酶 DHX9 的 SUMOylation 对于解决 R 循环和保持基因组稳定至关重要. 这种修饰调节蛋白相互作用,防止DNA损伤和细胞死亡.

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