在COVID-19幸存者的肺功能轨迹中,有或没有先前存在的呼吸道疾病
Debbie Gach1,2, Rosanne J H C G Beijers1, Roel van Zeeland3
1Department of Respiratory Medicine, NUTRIM, Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
患有先前存在的呼吸道疾病 (PRD) 的COVID-19幸存者在住院一年后显示持续减少的肺扩散能力. 非PRD患者表现出一定程度的康复,突出显示COVID-19对肺功能的长期影响.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 住院COVID-19幸存者经常经历持续的肺功能障碍.
- 减少肺扩散能力是影响长期康复的常见后果.
- 预先存在的呼吸道疾病 (PRD) 对COVID-19肺部恢复轨迹的影响尚未完全理解.
研究的目的:
- 为了比较住院COVID-19患者的肺功能轨迹,这些患者有或没有先前存在的呼吸系统疾病 (PRD).
- 在出院后3个月和12个月评估肺扩散能力的变化.
- 为了确定PRD和非PRD组之间的恢复模式的差异.
主要方法:
- 在239名住院COVID-19患者的单中心回顾性队列研究中.
- 肺功能测试在出院后的3个月和12个月进行.
- 根据扩散容量的正常值的下限定义的损伤.
主要成果:
- 三个月后,64%的PRD患者和49%的非PRD患者的扩散能力较低.
- 没有PRD的患者在12个月内显著改善了扩散能力 (p=0.003).
- 患有PRD的患者在十二个月后表现出持续低的扩散能力,没有显著改善 (p=0.250).
结论:
- 住院的COVID-19患者,无论有没有PRD,都会经历显著的肺功能障碍,主要是扩散能力降低.
- 虽然非PRD患者出现恢复,但PRD患者的肺扩散能力长期恢复不佳.
- 预先存在的呼吸道疾病是影响COVID-19幸存者的长期肺部结果的关键因素.
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