这种药物会使人脑失调
Joshua S Siegel1, Subha Subramanian2, Demetrius Perry3
1Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. jssiegel@wustl.edu.
Nature
|July 17, 2024
概括
单剂量西会迅速影响大脑连接, 破坏网络并可能带来治疗效果. 这些变化, 特别是在默认模式的网络, 持续数周,
科学领域:
- 神经科学
- 心理药理学
- 神经成像
背景情况:
- 在人类中具有快速治疗效果, 在动物中引起神经可塑性.
- 大脑网络变化与迷幻药的长期影响之间的关系尚不清楚.
研究的目的:
- 通过纵向功能映射来研究在施用psilocybin后个体特异性的脑网络变化.
- 这些大脑变化与主观经验相关联, 并评估它们的持续性.
主要方法:
- 在高剂量psilocybin (25 mg) 和methylphenidate (40 mg) 服用前,服用期间和服用后3周内对健康成年人进行长度精确功能映射 (fMRI).
- 评估功能连接 (FC) 变化,网络区别,以及前海马和默认模式网络之间的连接.
- 追踪参与者6至12个月,以获得第二剂psilocybin,并评估持续效应.
主要成果:
- 这种药物对皮质和皮质下功能连接造成了显著的,与剂量相关的干扰,超过了甲基酸的作用.
- 大脑失同减少了网络区别, 默认模式网络的变化最明显.
- 个人CF变化与主观迷幻体验相关.
- 在施用psilocybin后的几周内,观察到前海马和默认模式网络之间的FC持续下降.
结论:
- 这种药物会严重破坏大脑的功能连接,
- 持续减少海马-默认模式的网络连接可能是迷幻药物治疗潜力的基础.
- 每个人的脑反应与主观效应有关,这表明个性化治疗机制.
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