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Updated: Jun 20, 2025

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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克隆性失活TERT会损害干细胞的竞争

Kazuteru Hasegawa1,2,3, Yang Zhao4, Alina Garbuzov1,2,3

  • 1Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|July 17, 2024
PubMed
概括

端粒酶逆转录酶 (TERT) 增强了干细胞的竞争力,而这与其催化功能无关. TERT影响干细胞命运和MYC瘤基因活动,影响克隆形成和基因组调节.

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