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Updated: Jun 20, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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综合分析强调了三维基因组与转移性前列腺癌中的DNA,RNA和表观基因组变化之间的相互作用

Shuang G Zhao1,2,3, Matthew Bootsma1, Stanley Zhou4,5

  • 1Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA.

Nature genetics
|July 17, 2024
PubMed
概括

前列腺癌的基因组结构变异会影响基因表达和甲基化. 与染色体外DNA (ecDNA) 相关的特定染色质变化与针对雄激素受体 (AR) 的治疗反应不佳相关.

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