血清胆红素在生理范围内的血清胆红素和血清丸激素水平之间存在正相关性
Cunbao Ling1, Yadong Liu2,3, Meiling Yao4
1School of Basic Medical Sciences, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu Province, China.
BMC endocrine disorders
|July 17, 2024
概括
血清总 bilirubin (STB) 的升高与成人男性的血清丸激素 (STT) 水平的升高有关. 较高的STB可能会对缺乏症 (TD) 风险产生保护作用.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 临床生物化学 临床生物化学
背景情况:
- 血清总 bilirubin (STB) 的升高显示在代谢综合征有有益影响.
- 调查STB和血清丸激素 (STT) 之间的联系对于了解缺乏症 (TD) 至关重要.
研究的目的:
- 检查成年男性的STB和STT水平之间的关联.
- 为了确定胆红素是否对TD风险起着保护作用.
主要方法:
- 来自国家健康和营养检查调查 (NHANES) (2011-2016) 的 6,526 名男性参与者的分析.
- 利用加权多变量回归模型和受限立方线 (RCS) 来评估STB-STT关系.
- 进行了子组分析,以确定不同人群中关联的变化.
主要成果:
- 在STB和STT水平之间发现了显著的正相关性 (P < 0.0001).
- 增加的STB与TD的可能性降低有关 (OR=0.96,P < 0.0001).
- 在老年,非吸烟/饮酒和肥胖男性中观察到保护性关联.
结论:
- 在生理范围内的STB与成年男性的STT有积极的联系.
- 胆红素在维持丸激素水平方面的潜在保护作用需要进一步研究.
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