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移植中的生物标志物:一个快速发展的景观
Gaurav Gupta1,2, Akshay Athreya2, Ashish Kataria3
1Hume-Lee Transplant Center, Virginia Commonwealth University, Richmond, VA.
Transplantation
|July 18, 2024
概括
非侵入性生物标志物,如来自捐赠者的无细胞DNA (dd-cfDNA),在移植中表现有前途. 增加的dd-cfDNA表明严重损伤,并预测更糟糕的移植结果,指导个性化免疫抑制策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植免疫学 移植免疫学
- 生物标志物发现发现
背景情况:
- 非侵入性生物标志物在移植研究中变得越来越重要.
- 捐赠者衍生的无细胞DNA (dd-cfDNA) 是一个关键的焦点,最初用于排斥,现在作为严重损伤的标志物.
- 其他生物标志物包括血液基因表达,Torque teno病毒和尿路化学因子.
研究的目的:
- 审查移植中非侵入性生物标志物的当前情况.
- 评估dd-cfDNA,基因表达,病毒标记物和尿路化学因子的有用性.
- 探索针对个性化免疫抑制的多模式测试的潜力.
主要方法:
- 对移植中的非侵入性生物标志物发表文献的综述.
- 对来自供体的无细胞DNA (dd-cfDNA) 的数据及其预后价值的分析.
- 评估新出现的生物标志物,如Torque teno病毒和尿路化学因子 (CXCL9,CXCL10).
主要成果:
- 较高的dd-cfDNA (≥0.5%) 表示严重的代移植损伤,预示着更糟糕的结果.
- 血液基因表达造型显示出早期亚临床排斥检测的潜力,但需要验证.
- 扭矩病毒副本数可能反映免疫抑制水平.
- 尿中的化学基因 (CXCL9,CXCL10) 显示出早期拒绝诊断和预后的前景.
结论:
- 非侵入性生物标志物正在推进脏移植监测.
- dd-cfDNA是严重的全移植损伤的关键指标.
- 未来对多模式测试和连续监测的研究可能会使个性化免疫抑制和早期干预成为可能.
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