肠道微生物群在探索病因学,多微生物病原体和疾病发病率方面的最新作用
Jin-Bo Xiong1,2, Hao-Nan Sha1,2, Jiong Chen1,2,3
1State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo, Zhejiang 315211, China.
Zoological research
|July 18, 2024
概括
利托佩内乌斯 (Litopenaeus vannamei) 水产养殖面临的挑战是频繁的疾病爆发. 本综述探讨了疾病期间肠道微生物组的变化,并提出了识别多微生物病原体和预测疾病发病率的方法.
科学领域:
- 水产养殖是水产养殖的一种方式.
- 微生物学 微生物学
- 动物卫生 动物健康
背景情况:
- 利托佩内乌斯 (Litopenaeus vannamei) 水产养殖在经济上具有重要意义,但受到疾病爆发的威胁.
- 病因学研究往往滞后,导致病原体未被识别,疾病命名是基于症状的.
- 关于病状况及其对肠道微生物群的影响的数据有限.
研究的目的:
- 审查当前关于病及其对肠道微生物群的影响的知识.
- 为识别多微生物病原体和理解肠道微生物群动态提出工作流程.
- 开发一种用于预测病发病率的诊断模型.
主要方法:
- 对影响肠道微生物群的非生物和生物因素的分析.
- 强调全生物组概念和微生物群对疾病的反应.
- 使用疾病常见的歧视性种群和qPCR测试的功能基因开发诊断模型.
主要成果:
- 确定了影响肠道微生物群组成的关键因素.
- 提出了一种工作流程,将微生物种类和毒性基因集成为病原体识别.
- 基于肠道微生物群签名,开发了病发病率的预测模型.
结论:
- 肠道微生物群在病因学和多微生物病原体识别方面发挥着至关重要的作用.
- 使用疾病常见歧视性功能基因的诊断模型为水产养殖健康管理提供了一种实际的方法.
- 这一审查为推进养殖水产养殖健康提供了精细的视角.
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