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Updated: Jun 20, 2025

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
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乌斯尼克酸单化衍生物的设计,合成和活动评估

Qing Zhang1, Jun-Li He1, Xiao-Xia Zhuo1

  • 1School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Natural product research
|July 18, 2024
PubMed
概括

新的乌斯尼克酸衍生物显示出强大的抗微生物和抗菌膜活性. 这些化合物有效地抑制了Candida albicans和Staphylococcus aureus的生长和生物膜形成,提供了潜在的双重作用剂.

关键词:
在Candida albicans中使用.黄金葡萄球菌黄金葡萄球菌乌斯尼克酸是一种酸.生物膜是一种生物膜.单化衍生物的单化衍生物

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Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
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Amides are synthesized by treating carboxylic acids with amines in the presence of dehydrating agents like dicyclohexylcarbodiimide (DCC).
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Amides can undergo either acid-catalyzed hydrolysis or base-promoted hydrolysis through a typical nucleophilic acyl substitution. Each hydrolysis requires severe conditions.
Acid-catalyzed hydrolysis:
Hydrolysis of amides under acidic conditions yields carboxylic acids. Since the reaction occurs slowly, hydrolysis requires the conditions of heat.
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