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血清转移的趋势:揭示高血糖症与COVID-19疫苗接种后的联系

Mohammed Abdullah Ali Alghamdi¹, Turki Mohammed M Alqahtani¹, Mirza Rafi Baig²

¹Department of Biochemistry, Faculty of Science, King Abdul-Aziz University, Jeddah, 21589, Saudi Arabia.

Current medicinal chemistry

|July 18, 2024

概括

接种COVID-19疫苗可能会改变与2型糖尿病相关的生物标志物. 疫苗接种后未控制的糖尿病患者显示,LDH,肝酶和尿酸水平发生显著变化,这表明潜在的自身免疫联系.

科学领域:

内分泌学在内分泌学.
免疫学免疫学免疫学
生物化学生化学

背景情况:

在COVID-19疫苗接种后出现的内分泌并发症.
mRNA疫苗 (Pfizer-BioNTech,Moderna) 显示出有效性,但与糖尿病的潜在关联仍在探索中.
改变肝脏和功能测试疫苗接种后的证据调查对2型糖尿病的预测.

研究的目的:

在COVID-19疫苗接种后的个体中探索生化异常.
研究SARS-CoV-2疫苗接种,生物化学标记物和2型糖尿病之间的关系.
分析与疫苗接种状态和糖尿病控制有关的血清生物标志物转变.

主要方法:

潜在的病例控制研究涉及203名成人参与者,他们接受了三剂COVID-19疫苗.
参与者根据疫苗接种情况和之前的SARS-CoV-2暴露情况进行了选择;没有先前感染的人被排除在外.
分析包括人口特征,肝功能测试 (LFT),功能测试 (KFT),乳酸脱酶 (LDH) 和矿物离子水平.

主要成果:

在不受控制的糖尿病 (HbA1c >10%) 中观察到的显著变化:的减少,LDH的增加,性酸酶,GGT和血清胆红素的升高.
失控的糖尿病患者也表现出显著降低肌氨酸和尿酸水平的升高.
大多数患有失控糖尿病的人属于O+血型.

结论:

血清生物标志物的显著变化与mRNA COVID-19疫苗接种和糖尿病有关,特别是在不受控制的情况下.
研究结果表明,mRNA疫苗成分可能引发潜在的自身免疫反应.
需要进一步的研究来澄清潜在的病理生理机制,并验证这些发现,考虑到血型和种族差异的潜在影响.

关键词:

这是ABO血型,ABO血型.KFT KFT KFT KFT KFT KFT KFT KFT KFT KFT KFT KFT KFT KFT KFT KFT KFT KFT KFT 在 LDH 和 LDH 之间.在LFT中,LFT是最重要的.血清的转移是血清的转移.血糖过高的高血糖症是什么的含量是多少? 的含量是多少?接种疫苗后的时间

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