早期血管衰老门诊评分 (EVAAs) 的评估:一个基于大量人群的外部验证研究
Christina Antza1, Victoria Potoupni1, Evangelos Akrivos2
13rd Department of Internal Medicine, Aristotle University, Hypertension-24h ambulatory blood pressure monitoring center, Papageorgiou Hospital, Thessaloniki, Greece.
Current vascular pharmacology
|July 18, 2024
概括
早期血管衰老门诊评分 (EVAAs) 可靠地预测动脉硬性和早期血管衰老 (EVA),在临床实践中为脉冲波速度 (PWV) 提供了更简单的替代方案.
科学领域:
- 心脏病学 心脏病学
- 血管医学 血管医学
- 生物医学工程 生物医学工程
背景情况:
- 脉冲波速度 (PWV) 是评估早期血管衰老 (EVA) 和动脉硬性的黄金标准.
- 目前的PWV方法是昂贵的,耗时的,需要专门的人员.
- 需要可访问的替代方法来评估EVA.
研究的目的:
- 为了外部验证新开发的早期血管衰老门诊评分 (EVAAs).
- 评估EVAAs作为预测EVA风险的简化工具.
- 为了比较EVAA与带带PWV (c-f PWV) 的预测性能.
主要方法:
- 在来自高血压ESH卓越中心的879名患者的独立队列中对EVAA的外部验证.
- 使用c-f PWV测量和EVAAs工具进行了EVA评估.
- 在EVAA和c-f PWV之间对EVA预测准确性的比较.
主要成果:
- EVAAs显示了EVA的高预测准确性,具有0.98的灵敏度和0.75的特异性.
- 这些EVAA显示了95%的正预测值和92%的负预测值.
- 与c-f PWV相比,平均平方误差 (MSE) 在EVA预测中没有统计学上显著的差异.
结论:
- EVAAs是识别EVA患者的可靠工具,可以与c-f PWV相比较.
- EVAA为EVA风险评估提供了一种简化且可能更容易获得的方法.
- 建议EVAAs作为常规临床实践中一个有价值的工具.
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