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Updated: Jun 20, 2025

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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在高风险神经母细胞瘤中,由PRMT5驱动的持续癌症相关的替代RNA剪接事件

Laurel Tabe Bate-Eya1, Gulsah Albayrak1, Simon Mark Carr1

  • 1Laboratory of Cancer Biology, Department of Oncology, University of Oxford, UK.

Molecular oncology
|July 18, 2024
PubMed
概括

蛋白质氨酸甲基转移酶5 (PRMT5) 和E2F1在高风险神经母细胞瘤中过度表达,导致异常RNA拼接阻断细胞亡. 向PRMT5可能会恢复这些侵袭性癌症的亡敏感性.

关键词:
E2F1 E2F1 E2F1 E2F1 E2F1 E2F1 E2F1 E2F1在PRMT5中,替代性RNA拼接是一种替代性的RNA拼接.灭症 (apoptosis) 是一种死亡的过程.神经母细胞瘤的神经母细胞瘤治疗目标是治疗的目标.

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