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促进牙肉质再生:从干细胞/原生细胞移植中获得的临床观点和见解 (第二部分)

Sayna Shamszadeh¹, Mohammad Jafar Eghbal¹, Saeed Asgary¹

¹Iranian Center for Endodontic Research, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Science Tehran, Iran.

American journal of stem cells

|July 18, 2024

概括

干细胞移植在成熟和不成熟的牙中显示出再生性内牙科的前景,改善了放射和临床结果. 然而,有限的高质量研究需要谨慎的解释和进一步的研究.

科学领域:

牙周内科医院牙周内科医院牙周内科医院
再生医学是一种再生医学.
干细胞生物学干细胞生物学

背景情况:

再生性内牙术的目的是用重要的功能性组织取代受损的脉组织.
干细胞移植是成熟和不成熟牙再生性内牙科的一个关键策略.
现有临床证据需要综合评估疗效和局限性.

研究的目的:

系统地审查关于再生性内牙科中干细胞移植的临床研究.
评估这些程序的放射和临床结果.
为了确定使用的干细胞类型,支架和生长因子.

主要方法:

在Scopus,PubMed,ISI Web Science和Google Scholar的系统电子文献搜索到2023年1月.
包括随机对照试验 (RCT),病例报告和病例系列.
评估放射性参数 (损伤大小,根长度等) 的评估. 和临床参数 (疼痛,敏感性).

主要成果:

在3250篇文章中选择了5项临床研究 (2项RCT,3项病例报告/系列).
牙髓干细胞 (DPSCs) 在不成熟的牙中增加了根长;带介质干细胞 (UC-MSCs) 在成熟的牙中减少了尖端病变.
在各种干细胞应用中观察到积极的脉反应,增加血流和矿化.

结论:

干细胞移植有可能在成熟和不成熟的牙中进行再生性内牙科.
发现了干细胞类型,支架和生长因子的异质性.
目前的证据基础有限,存在偏见的风险,需要进一步进行高质量的临床试验.

关键词:

丹丁-纸复合物丹丁-纸复合物牙髓干细胞是牙髓的干细胞.再生性内牙科是指再生性内牙科.干细胞移植干细胞移植系统性审查系统性审查

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