与nocebo效应相关的风险因素:对评论的综述
Francesca Grosso1,2, Diletta Barbiani1, Cesare Cavalera1
1Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy.
Brain, behavior, & immunity - health
|July 18, 2024
概括
确定了对nocebo效应的风险因素,这些风险因素会对健康结果产生负面影响. 以前的期望,患者与医生的关系和治疗细节显著影响这些不良反应.
科学领域:
- 医学研究 医学研究
- 精神病体医学是一种精神病体医学.
- 临床药理学 临床药理学
背景情况:
- 由于负面期望导致的负面健康结果的标志是nocebo效应,在临床实践中构成了重大挑战.
- 了解与nocebo效应相关的预测因素和风险因素对于制定缓解策略至关重要.
研究的目的:
- 系统地识别和分类导致nocebo效应的各种风险因素.
- 综合当前关于nocebo现象决定因素的知识.
主要方法:
- 对文学进行了全面的元综述,搜索了五个主要的数据库和灰色文学.
- 在评估方法学有效性和偏差风险后,包括了43项相关的综述研究.
- 采用专题分析来综合包括在内的审查中的发现.
主要成果:
- 确定了九个不同的风险因素类别:先前的期望,社会人口统计学,人格,神经退行性和炎症状况,沟通,药物特征,环境和自我意识.
- 阐明了导致nocebo效应的关键生化和神经生理机制.
- 之前的负面经历和预期被强调为nocebo反应的主要触发因素.
结论:
- 诺塞博效应主要是由对不良症状的预期驱动的,这些症状往往源于先前的负面经历.
- 一个强大的患者与医生的关系和清晰的,个性化的治疗沟通可以作为保护因素.
- 这些发现对管理患者期望和优化治疗结果具有重大临床影响.
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