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在晚期胃癌中比较近端胃切除术和全胃切除术后的存活率:系统性审查和元分析

Ping-Jui Su¹, Yen-Ta Huang², Ting-Kai Liao^1,3

¹Division of General Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan, R.O.C.

Oncology letters

|July 18, 2024

概括

靠近胃切除术 (PG) 与全胃切除术 (TG) 相比,在局部晚期胃癌 (GC) 中提供了可比或改善的长期存活率. 这一元分析强调了PG作为特定GC病例的潜在优越外科选择.

科学领域:

手术瘤学手术瘤学
胃肠病学胃肠病学
基于证据的医学基于证据的医学.

背景情况:

局部发达的胃癌 (GC) 存在重大治疗挑战.
手术治疗,包括近腹切除术 (PG) 和全腹切除术 (TG),是治疗的基石.
这些程序后的长期生存结果需要仔细评估.

研究的目的:

系统地审查和分析近端胃切除术 (PG) 和全胃切除术 (TG) 后的长期存活率.
为了比较局部晚期近位胃癌患者的整体存活率 (OS),这些患者接受了PG或TG治疗.

主要方法:

发表的双臂前性或后性研究的系统审查和元分析.
在PubMed,EMBASE和Cochrane CENTRAL数据库中搜索到2023年5月.
包括报告局部晚期GC患者PG或TG治疗的定量生存结果的研究.

主要成果:

包含了三项涉及4815名患者的研究.
分析显示,与TG相比,PG与改善的整体存活率 (OS) 之间存在显著的关联 (组合危险比:1.15;95% CI,1.05-1.25)).
在包括的研究中没有观察到异质性 (I2=0%).

结论:

靠近胃切除术 (PG) 与全胃切除术 (TG) 相比,在治疗局部晚期胃癌 (GC) 方面,长期整体存活率 (OS) 相当或略有改善.
对于某些患有局部发达近端GC的患者,PG可能是有利的外科治疗方法.
需要进一步的元分析来巩固这些发现并提供更强有力的证据.

关键词:

局部发达的胃癌在当地发达的胃癌.进行元分析.靠近的胃切除术靠近的胃切除术幸存率幸存率生存率系统性审查系统性审查整体胃切除术整体胃切除术

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