肺癌中外体lncRNA/circRNA-miRNA-mRNA轴的最近进展:对临床应用的含义
Ren Wang1, Yiwei Xu2, Liangjing Tong3
1Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Frontiers in molecular biosciences
|July 18, 2024
概括
液体活检中的外体内含有非编码RNA,对肺癌进展至关重要. 这些外体RNA,通过竞争性内源RNA机制,为早期肺癌诊断和向治疗提供了潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 肺癌是全球癌症死亡的主要原因,通常在晚期被诊断出来.
- 液体活检,特别是外体分析,显示了早期肺癌检测的前景.
- 外基因组含有非编码RNA (lncRNA,circRNA,miRNA) 在癌症发育中至关重要.
研究的目的:
- 审查外体非编码RNAs在肺癌中的作用.
- 阐明涉及这些分子的竞争性内源RNA (ceRNA) 网络的相互作用.
- 在肺癌中呈现经过验证的外体非编码RNA调节的基因轴.
主要方法:
- 对肺癌中外体非编码RNA现有研究的文献综述.
- 对竞争性内源性RNA (ceRNA) 机制的分析.
- 鉴定和验证由肺癌衍生的外体非编码RNA调节的基因轴.
主要成果:
- 外体非编码RNAs (lncRNAs,circRNAs,miRNAs) 与肺癌致癌,诊断,治疗和耐药性有关.
- 在ceRNA网络中,lncRNAs/circRNAs竞争miRNAs,影响mRNA表达和肺癌的进展.
- 确定了对肺癌中调节基因的外体非编码RNA的验证轴.
结论:
- 外体非编码RNA在肺癌的发病和进展中起着至关重要的作用.
- lncRNA/circRNA-miRNA-mRNA轴为肺癌诊断,预后和治疗策略提供了一个有前途的途径.
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