制造pH刺激水凝作为生物活性材料用于伤口愈合应用
Liang Cheng1, Song Zhang1, Qian Zhang1
1Department of Burns and Plastic Surgery, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
Heliyon
|July 18, 2024
概括
由碳氧甲基纤维素,聚乙烯醇和凝制成的新生物聚合物水凝显示出作为先进的伤口带的前景. 这些材料模仿细胞外基质,并表现出可调节的胀和药物释放特性,以有效的伤口愈合.
科学领域:
- 生物材料科学 生物材料科学
- 伤口愈合 治愈 伤口愈合
- 药物运输 药物运输 药物运输
背景情况:
- 由于其3D结构,水凝是伤口合剂的优秀候选者.
- 模仿自然的细胞外基质对于有效的伤口愈合应用至关重要.
- 开发先进的伤口包裹需要具有可调节性质的材料.
研究的目的:
- 用于制造碳素甲基纤维素 (CMC),聚乙醇 (PVA) 和凝的水凝.
- 评估制造的水凝的物理化学特性和细胞兼容性.
- 评估这些水凝作为增强愈合的伤口带的潜力.
主要方法:
- 水凝是使用简单的混合方法与CMC,PVA和凝制造的.
- 描述包括扫描电子显微镜 (SEM),水接触仪 (WCM) 和富里埃变换红外光谱 (FTIR).
- 评估了胀,降解,药物释放 (Neomycin),细胞相容性 (纤维细胞3T3细胞) 和血管生成 (HEK 293细胞).
主要成果:
- 根据配方,水凝表现出不同的湿和降解行为.
- 与酸盐缓冲盐水 (PBS) 相比,在水性介质中观察到较高的胀比率.
- 已经证明了pH响应性Neomycin释放和良好的细胞相容性和血管生成促进.
结论:
- 制造的CMC/PVA/凝水凝具有适用于伤口合剂应用的特性.
- 这些水凝通过受控的药物释放和生物相容性显示出促进伤口愈合的潜力.
- 这些水凝的调节性质使它们成为先进伤口护理的有希望的候选者.
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