在早期乳腺癌的碳离子辐射治疗后,内血流的变化
Kenta Ohmatsu1, Tokuhiko Omatsu2, Noriyuki Okonogi2,3
1Department of Radiation Oncology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
International journal of particle therapy
|July 18, 2024
概括
接受碳离子辐射疗法 (CIRT) 的早期乳腺癌患者表现出显著的瘤血流变化. 治疗后的Washin指数值预测了12个月内临床完整反应.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 医疗成像医学成像
背景情况:
- 早期乳腺癌的治疗往往涉及到放射治疗.
- 碳离子辐射疗法 (CIRT) 是一种先进的放射治疗技术.
- 早期评估治疗反应对于患者管理至关重要.
研究的目的:
- 在早期乳腺癌中,在CIRT后量化内血流变化.
- 分析这些血流变化的临床意义.
- 识别可预测治疗反应的成像生物标志物.
主要方法:
- 研究了38名接受CIRT的早期乳腺癌患者.
- 动态对比增强型MRI用于测量washin和washout指数.
- 在CIRT之前和之后,也评估了明显扩散系数.
主要成果:
- 瘤大小,washin指数和washout指数在CIRT后1个月显著下降.
- 显而易见的扩散系数在CIRT后的一个月显著增加.
- 在CIRT后1个月和3个月的Washin指数值与12个月内临床完整响应 (cCR) 有关.
结论:
- 与对比度增强的MRI可以量化乳腺癌中CIRT后的早期瘤变化.
- 华信指数是一种潜在的成像生物标志物,用于预测CIRT的早期治疗反应.
相关概念视频
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...