高剂量潘托普拉治疗胃食道逆流性疾病:需要,证据,指南和我们的经验
Rajesh Upadhyay1, Navin K Soni2, Ashwin A Kotamkar3
1Department of Gastroenterology, Max Super Speciality Hospital, Shalimar Bagh, New Delhi, India.
Euroasian journal of hepato-gastroenterology
|July 18, 2024
概括
每天服用一次更高剂量的潘托普拉 (80毫克) 可能会改善胃食道逆流性疾病 (GERD) 患者的结果,这些患者需要更多的酸性抑制. 这种方法提高了与每天两次剂量相比的合规性.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胃食道逆流性疾病 (GERD) 影响了印度15.2%的人口.
- 质子抑制剂 (PPI) 是由于疗效和安全性而首选的GERD治疗方法.
- 潘托普拉 (Pantoprazole) 是印度常见的处方PPI.
研究的目的:
- 审查科学证据和临床经验,支持高剂量潘托普拉 (80毫克) 每天一次用于GERD.
- 为了解决在特定患者子组中标准松普拉剂量的局限性.
- 突出提高每日一次高剂量治疗的遵守能力的潜在好处.
主要方法:
- 审查现有的科学文献关于PPI对GERD的剂量.
- 对临床指南的分析,建议增加PPI剂量.
- 讨论临床医生与更高剂量的潘托普拉治疗的经验.
主要成果:
- 对于患有食道外症状,部分反应,NSAID使用或肥胖的患者,标准潘托普拉 (40 mg) 不足.
- 在这些具有挑战性的情况下,指南建议将PPI剂量增加一倍.
- 每天服用一次80毫克的潘托普拉可能会提供更好的遵守和持续的酸性抑制.
结论:
- 高剂量的潘托普拉 (80毫克) 每天服用一次,对于特定的GERD患者群体是可行的选择.
- 更好地遵守每天一次的剂量可以导致更好的治疗结果.
- 双释放80毫克潘托普拉可能会提高酸性抑制的持续时间和患者的坚持.
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