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Updated: Jun 20, 2025

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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研究特里斯-胺胺作为雌激素受体调节器,结合调节器的结构-活性关系

Tae-Kyung Lee1, Kara Kassees1, Chia-Yuan Chen1

  • 1Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.

ACS pharmacology & translational science
|July 18, 2024
PubMed
概括

雌激素受体调节器结合调节器 (ERXs) 为克服乳腺癌内分泌抵抗提供了一种新方法. 优化ERX化合物18h显示显著增强的结合亲和力和强大的抗瘤活性对ERα阳性乳腺癌.

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