豆类和芝麻口服食品挑战结果
Jacob J Pozin1, Ashley L Devonshire1,2,3, Kevin Tom1
1From the Department of Medicine, Northwestern Feinberg School of Medicine, Chicago, IL.
Journal of food allergy
|July 18, 2024
概括
豆类的口服食品挑战 (OFC) 往往会带来轻微的反应. 然而,芝麻OFC更频繁地失败,反应更严重,特定免疫球蛋白E (sIgE) 水平和结果之间没有相关性.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科胃肠病学 儿科胃肠病学
- 临床营养学 临床营养学
背景情况:
- 豆类和芝麻过敏越来越被认为是严重的公共卫生问题.
- 特定免疫球蛋白E (sIgE) 测试用于预测对豆类和芝麻的临床反应性的诊断实用性仍然不清楚.
- 了解这些过敏症对于有效的临床管理和患者的治疗结果至关重要.
研究的目的:
- 评估口服食品挑战 (OFC) 对豆类和芝麻过敏的临床结果.
- 评估特定免疫球蛋白E (sIgE) 水平与儿科患者的OFC结果之间的相关性.
- 提供关于OFCs期间反应的严重程度和管理的见解.
主要方法:
- 2007年至2017年间对74个豆类和芝麻OFC进行的回顾性审查.
- 收集豆类和芝麻的临床数据,OFC结果和sIgE水平.
- 生成接收机操作特征曲线和物流回归模型来预测OFC结果.
主要成果:
- 豆类OFC的通过率很高 (84.9%),大多数反应不严重.
- 芝麻OFC的合格率较低 (61.0%),与豆类相比,失败率几乎是豆类的两倍.
- 对失败的芝麻OFC的反应往往更严重,包括过敏反应,芝麻sIgE水平与OFC结果无关.
结论:
- 豆类OFCs通常耐受良好,在失效时会出现轻微反应.
- 芝麻OFC具有更高的失败风险和更严重的反应,强调需要仔细评估.
- 目前对芝麻的sIgE测试可能无法准确预测临床反应性,这表明其诊断价值受到限制.
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