量化由红外神经刺激引起的组织温度变化:数值模拟和MR温度计.
Yinghua Xi1,2, Kenneth E Schriver3, Anna Wang Roe1,2,4,5
1Interdisciplinary Institute of Neuroscience and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University , Hangzhou 310027, China.
Biomedical optics express
|July 18, 2024
概括
红外神经刺激 (INS) 是大脑研究和临床应用的一个有前途的技术. 这项研究量化了INS期间的温度变化,发现典型的参数使组织变暖低于损伤值,确保安全.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 生物物理学的生物物理.
背景情况:
- 红外神经刺激 (INS) 使用光热转换用于神经元去极化.
- 鉴于潜在的脑组织损伤,评估热安全至关重要.
- 对于中枢神经系统热效应的定量数据是有限的.
研究的目的:
- 在INS期间量化测量和模拟ex vivo大鼠大脑中的温度变化.
- 评估INS参数对生物组织的安全性.
主要方法:
- 7特斯拉核磁共振扫描仪在外生老鼠大脑上使用.
- 红外脉冲火车的强度在0.1-1.0 J/cm2.0之间.
- 一般生物热传递模型 (GBHTM) 模拟了温度变化.
主要成果:
- INS脉冲列车造成了短暂的温度升高,随后发生了快速降温.
- 短时间间隔的多个脉冲列车导致温度高原.
- 温度上升在0.1-0.5 J/cm2下保持在1°C以下,在1.0 J/cm2下保持在2°C以下,在安全范围内.
结论:
- 在生物应用中常用的INS参数会导致最小的,无害的温度升高.
- 该研究提供了量化证据,支持当前INS实践对大脑组织的安全性.
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