使用基于多通道细胞的近红外气体传感器对甲进行实时呼吸气体分析
Rong Kong1, Jie Huang1, Peng Liu1
1Center for Advanced Quantum Studies, Applied Optics Beijing Area Major Laboratory, Department of Physics, Beijing Normal University , Beijing 100875, China.
Biomedical optics express
|July 18, 2024
概括
一个新的近红外传感器使用可调节二极管激光吸收光谱 (TDLAS) 进行实时甲呼吸分析. 这种非侵入性设备在高灵敏度和速度的诊断肠道问题方面表现有前途.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 频谱学是一种光谱学.
背景情况:
- 呼出的气息中的甲是胃肠道疾病的潜在生物标志物.
- 对肠道问题的非侵入性诊断方法非常受欢迎.
研究的目的:
- 开发和验证近红外传感器,以实时检测呼出气中的甲.
- 评估传感器在非侵入性疾病诊断方面的潜力.
主要方法:
- 使用可调节二极管激光吸收光谱仪 (TDLAS) 采用双镜,九圈多通道细胞.
- 在一个紧的体积 (233.3厘米3) 中实现了长光路径长度 (23.4米).
- 采用波长调制光谱来提高检测极限和响应时间.
主要成果:
- 甲的最低检测极限为0.37ppm,比直接吸收光谱学提高了12.4倍.
- 实现了0.6秒的快速气体交换时间.
- 在6名人类志愿者中验证了实时甲测量能力.
结论:
- 开发的TDLAS传感器为呼吸甲分析提供了高灵敏度,选择性和快速响应.
- 该传感器具有重要的潜力,用于肠道疾病的非侵入性,实时,即时诊断.
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