在不同癌症中,JAK/STAT通路与非编码RNA之间的相互作用
Ammad Ahmad Farooqi1, Abay M Shepetov2, Venera Rakhmetova3
1Department of Molecular Oncology, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.
Non-coding RNA research
|July 18, 2024
概括
简氏激酶/信号转换器和转录激活器 (JAK/STAT) 途径对于癌症进展和免疫反应调节至关重要. 非编码RNA显著调节这种途径,影响瘤微环境和转移.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 简氏激酶/信号转换器和转录激活器 (JAK/STAT) 途径是一个关键的信号级联,涉及致癌和转移.
- 对JAK/STAT信号的放松调节会影响瘤的微环境和免疫反应.
- 越来越多地认识到JAK/STAT信号和非编码RNA (ncRNA) 之间的相互作用在癌症进展中的作用.
研究的目的:
- 在初级和转移性瘤中审查微RNA,长非编码RNA (lncRNA) 和圆形RNA (circRNA) 调节JAK/STAT通路的情况.
- 突出JAK/STAT信号在癌症转移和免疫细胞调节中的作用.
- 确定知识差距,并倡导在癌症治疗中对ncRNAs的临床翻译.
主要方法:
- 文献综述侧重于JAK/STAT通路,非编码RNA和癌症.
- 对巨分化和免疫细胞透中的STAT信号的机制性见解的分析.
- 对不同癌症阶段的JAK/STAT的ncRNA调节现有知识的综合.
主要成果:
- JAK/STAT信号驱动癌症转移并重塑瘤微环境.
- STAT信号促进M2巨细胞的两极分化,有助于疾病的攻击性.
- 通过ncRNAs调节JAK/STAT通路的活动,通过PD-L1/PD-1信号传递影响免疫细胞透 (例如NK,CD4/CD8细胞).
结论:
- JAK/STAT通路是癌症进展和免疫逃避的中央调节者.
- 微RNAs,lncRNAs和circRNAs代表了癌症中JAK/STAT通路的关键调节元素.
- 需要进一步的研究来弥合知识差距,并将关于lncRNAs和circRNAs的发现转化为癌症治疗的临床应用.
相关概念视频
The JAK-STAT Signaling Pathway
8.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.8K
Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
PI3K/mTOR/AKT Signaling Pathway
3.5K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.5K
Non-Canonical Wnt Signaling Pathways
7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K


