相关实验视频

Updated: Jun 20, 2025

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

感染或接种疫苗后的红疹病毒血清阳性作为多发性硬化症的危险因素

Jens Ingvarsson¹, Viktor Grut¹, Martin Biström¹

¹Department of Clinical Sciences, Neurosciences, Umeå University, Umeå, Sweden.

European journal of neurology

|July 18, 2024

概括

早期的红疹病毒 (RV) 感染可能会增加多发性硬化症 (MS) 风险,特别是在未接种疫苗的人群中. 这项研究表明,病毒在多发性硬化症的发展中起着更广泛的作用,可能是通过分子模仿.

科学领域:

神经免疫学神经免疫学
病毒学病毒学
流行病学流行病学

背景情况:

多发性硬化症 (MS) 是一种复杂的神经系统疾病,具有已知的遗传和环境风险因素.
爱斯坦-巴尔病毒 (EBV) 和人类疹病毒6A (HHV-6A) 都与MS的发病有关.
由于有限和相互矛盾的证据,其他神经向病毒,如红疹病毒 (RV) 在MS中的作用仍然不清楚.

研究的目的:

调查红疹病毒 (RV) 的血清反应与患多发性硬化症 (MS) 的风险之间的关联.
探索RV在多发性硬化症病原发生的潜在作用,考虑疫苗接种状态和其他病毒感染.

主要方法:

一项嵌套病例控制研究使用来自瑞典队列的生物库样本进行.
在MS发作之前,在接种疫苗和未接种疫苗的受试者中,使用基于珠子的多重检测分析了对RV的血清反应.
使用条件后勤回归来评估VR血清阳性和MS风险之间的关联,并对混因素进行调整.

主要成果:

对RV的血清阳性与未接种疫苗的人群中MS风险增加显著相关 (AOR=4.0,95% CI 1.8-8.8),即使在对EBV,HHV-6A,细胞巨血病毒和维生素D进行调整后也是如此.
与对照组相比,病例对红疹的抗体反应性更强,这种模式在其他疹病毒中没有观察到.
在接种疫苗的受试者中也发现了相关性,尽管在混调整后没有达到统计显著性 (AOR=1.7,95% CI 1.0-2.9).

结论:

这项研究提供了第一个证据,将早期红疹病毒的血清阳性与随后的MS发展联系起来.
这些发现支持扩大MS病因学中的"病毒假说".
红疹表位和中枢神经系统分子之间的分子模仿被认为是一种潜在的机制.

更多相关视频

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test

Published on: January 19, 2024

相关概念视频

Vaccinations

Vaccinations

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Mechanisms of Retrovirus-induced Cancers

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...

Cross-reactivity

Cross-reactivity

Viral Recombination

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.