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病毒的波林顿类超群:进化,分子生物学和分类学

Eugene V Koonin¹, Matthias G Fischer², Jens H Kuhn³

¹National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.

Microbiology and molecular biology reviews : MMBR

|July 18, 2024

概括

波林顿是一组移动基因元素,被重新分类为具有双重生活方式的病毒. 这项研究提出了一种新的病毒分类学,将多与其他DNA病毒联系起来,并揭示了进化关系.

科学领域:

病毒学病毒学
基因组学就是基因组学.
分子生物学分子生物学

背景情况:

波林顿是编码病毒结构蛋白的真核转位子,暗示了双转位子/病毒性质.
它们被归类为拟议的病毒类Polintoviricetes,类Preplasmiviricota.
相关元素包括腺病毒,波林顿类病毒 (PLV),病毒细胞和真菌等离子体.

研究的目的:

为了研究病毒的波林顿类超群内的进化关系.
根据基因组学和结构分析,为这些元素开发一个修改后的巨型taxonomy.
为了澄清细菌和真核DNA病毒之间的联系.

主要方法:

对波林顿类元素和相关病毒的族系学分析.
编码由多子的病毒蛋白质的比较结构分析.
利用进化见解构建一个新的病毒分类学.

主要成果:

在polinton编码的蛋白质中识别保存的功能域,包括终端蛋白和蛋白酶.
澄清了波林托病毒种中的进化关系.
建立了一个新的病毒大taxonomy,Polisuviricotina,包括Polintoviricetes,PLVs,病毒细胞和腺病毒.

结论:

类似波林顿病毒的病毒代表了一个重要的病毒超级组,提出了双重生活方式.
修订后的分类学为了解真核细胞DNA病毒的进化和多样性提供了一个强大的框架.
这项研究弥合了细菌和真核病毒的进化,突出了深层次的进化联系.

关键词:

腺病毒的病毒.波利顿波利顿是什么意思一种类似波林顿病毒的病毒.转换的意思是转换的意思.病毒菌体病毒菌体病毒分类学病毒分类学

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