Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein Folding01:25

Protein Folding

7.9K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
7.9K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

6.8K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
6.8K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

2.3K
2.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Comparing the Photophysical Properties of Bridged and Unbridged Platinum(II) Cyclometalated Complexes.

Inorganic chemistry·2026
Same author

Interplay between Slow Chirality Inversion and Slow Guest Uptake in a Triple-Helical Closed-Cage Metallocryptand.

Journal of the American Chemical Society·2026
Same author

Shape-Complementary Dimers of Simple Mononuclear Cobalt(III) Complexes Formed Through Eightfold Hydrogen Bonding.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Unidirectional cellulose nanocrystal hydrogel for bio-based invertible chiral optics and sensors.

Nature communications·2026
Same author

Cellulose nanocrystal gels as radical reservoirs.

Nanoscale·2026
Same author

Deceleration of Proton Exchange between Monosaccharides and Water by Metallocryptand and Related Compounds.

Inorganic chemistry·2026

相关实验视频

Updated: Jun 20, 2025

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
11:09

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

10.7K

在动态和准静态α-螺旋之间进行Redox触发的可逆切换.

Naoki Ousaka1,2, Mark J MacLachlan1,3,4, Shigehisa Akine1,5

  • 1Nano Life Science Institute (WPI-NanoLSI), Kakuma-machi, Kanazawa University, 920-1192, Kanazawa, Japan.

Chemistry (Weinheim an der Bergstrasse, Germany)
|July 18, 2024
PubMed
概括

研究人员开发了一种方法,可以使用氧化还原触发的二硫化键在动态和静态的α-螺旋之间进行可逆切换. 这种转换显著改变了螺旋体相互转换的速度,为质结构提供了新的控制.

关键词:
奇拉性是一种精神性.螺旋结构的螺旋结构.酸是一种酸.降解氧化物化学超分子化学 超分子化学

更多相关视频

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K
Author Spotlight: Photo Switchable Protein Recruitment for Reversible Patterning in Artificial Cellular Systems
07:10

Author Spotlight: Photo Switchable Protein Recruitment for Reversible Patterning in Artificial Cellular Systems

Published on: February 23, 2024

1.1K

相关实验视频

Last Updated: Jun 20, 2025

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
11:09

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

10.7K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K
Author Spotlight: Photo Switchable Protein Recruitment for Reversible Patterning in Artificial Cellular Systems
07:10

Author Spotlight: Photo Switchable Protein Recruitment for Reversible Patterning in Artificial Cellular Systems

Published on: February 23, 2024

1.1K

科学领域:

  • 超分子化学 超分子化学
  • 化学生物学 化学生物学
  • 酸科学 酸科学

背景情况:

  • 阿尔法螺旋是具有多种功能的关键生物分子.
  • 控制二次结构,如螺旋性,对于设计功能性来说至关重要.
  • 动态和静态结构具有不同的特性和应用.

研究的目的:

  • 为了实现单聚合动态和双聚合准静态α-螺旋之间的可逆转化.
  • 研究氧化还原触发二硫化键转换对螺旋性和相互转换率的影响.
  • 探索主刚度对右手 (P) 和左手 (M) 阿尔法螺旋相互转换的动力学的影响.

主要方法:

  • 合成双重接的α-螺旋,包括基于二硫化物的可逆接和基于双的固定接.
  • 使用tri-n-butylphosphine进行还原和4,4'-dithiodipyridine进行氧化以相互转换状态的氧化反应.
  • 1,1,2,2-四乙烯的动力学研究,以确定螺旋转化的半衰期,并评估P/M互转率.

主要成果:

  • 成功地证明了动态 (单接,dithiol) 和准静态 (双接,dissulfide) 的α-螺旋形式之间的可逆转变.
  • 在从动态转变为静态状态时,实现了P/M螺旋互转速率的~10^3倍变化.
  • 在双重接中确定了一种动力学上被困 (M) 丰富的形式,该形式在25°C下在约44天内转化为热力学稳定 (P) 丰富的形式.

结论:

  • 氧化引发的二硫醇/二硫化转换为控制α螺旋动力学和稳定性提供了有效的策略.
  • 开发的系统允许P/M螺旋互转率的显著调节,为基工程提供了一个新的工具.
  • 主的刚性在螺旋体相互转换的动力学中起着关键作用,灵活的主可以促进更快的转换.