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Updated: Jun 20, 2025

Rapid Generation of Amyloid from Native Proteins In vitro
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Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

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化溶解中的挑战 - 粉样蛋白病例研究

Oliwia Polańska1, Natalia Szulc2, Rafał Stottko3

  • 1Department of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370, Wroclaw, Poland.

Chemical record (New York, N.Y.)
|July 18, 2024
PubMed
概括

类溶解性是药物开发中的一个主要挑战. 本综述探讨了溶性差的原因,并分析了溶解困难序列的策略,包括粉样蛋白.

关键词:
聚合是一种聚合.溶解溶解是一种单质化的一元化.溶解度 溶解度 溶解度 溶解度困难的序列困难的序列

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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