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Leyang Wu^1,2,3, Liyuan Qiao¹, Shuhui Zhang¹

¹The State Key Laboratory of Pharmaceutical Biotechnology and Department of Neurology of Nanjing Drum Tower Hospital, School of Life Sciences and The Affiliated Hospital of Nanjing University Medical School, Nanjing University, Nanjing, Jiangsu, 210023, P. R. China.

Advanced materials (Deerfield Beach, Fla.)

|July 18, 2024

概括

一种新的双工程巨-微生物封装 (Du-EMME) 疗法有效地阻止了肺转移的进展. 这种创新的癌症治疗利用工程巨细胞和细菌来增强药物输送和抗瘤免疫力.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
生物技术是生物技术.

背景情况:

肺转移是癌症死亡的主要原因.
低效的药物输送和免疫抑制的瘤微环境阻碍了有效的癌症治疗.

研究的目的:

开发一种创新的双工程巨-微生物封装 (Du-EMME) 疗法,用于治疗癌症转移.
为了增强内药物递送和增强抗瘤免疫力.

主要方法:

为了增强瘤结合,开发出表达RGD的工程巨细胞 (R-GEM细胞).
R-GEM细胞与工程Salmonella typhimurium (VNP20009或VNP-IFNγ) 共同培养,以创建封装的巨细胞-微生物系统 (R-GEM/VNP或R-GEM/VNP-IFNγ细胞).
在乳腺癌,黑色素瘤和结直肠癌肺转移的小鼠模型中评估了Du-EMME治疗的疗效.

主要成果:

工程化巨细胞增强了瘤内的细菌丰富和生物活性.
在三种癌症类型中,Du-EMME疗法显著地阻止了肺转移性瘤的进展.
R-GEM/VNP-IFNγ细胞调节瘤微环境,抑制免疫抑制细胞并促进抗瘤免疫力.

结论:

杜-EMME疗法代表了针对癌症转移治疗的有希望的策略.
这种方法通过克服药物输送挑战和免疫抑制来增强抗瘤免疫力.
这种双重工程系统为开发先进的癌症免疫疗法提供了一个新的平台.

关键词:

工程化的巨细胞.免疫激活系统的激活微生物治疗学微生物治疗学沙门氏菌型菌 VNP200099 在线观看瘤向的分娩方式

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