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型肝炎病毒 (HCV) 基因型分布在托斯卡纳东南部:一项十年后期研究

Agostino Ognibene¹, Giulio Camarlinghi², Maria Lorubbio¹

¹Operative Unit of Chemical-Clinical Analysis; San Donato Hospital USL Toscana Sudest, Arezzo, Italy.

The new microbiologica

|July 18, 2024

概括

这项研究检查了2013-2022年东南托斯卡纳地区的C型肝炎病毒 (HCV) 发病率. 基因型1和3是最常见的,与患者年龄和性别相关的变异.

科学领域:

肝病学和病毒学.
公共卫生和流行病学

背景情况:

意大利是欧洲肝炎C病毒 (HCV) 患病率最高的国家.
托斯卡纳地区从2018年至2022年实施了慢性型肝炎控制计划.
托斯卡纳地区的HCV感染率约为0.8%.

研究的目的:

调查C型肝炎病毒 (HCV) 在托斯卡纳东南部的发病率和基因型分布.
在十年内分析特定人群中的HCV流行率和风险因素.
为 HCV 控制的区域公共卫生战略提供信息.

主要方法:

这是一项回顾性研究,分析了托斯卡纳州阿雷佐和格罗塞托 (Arezzo and Grosseto) 的246,137名患者 (2013-2022) 的数据.
对抗HCV抗体的查和HCV-RNA量化.
对阳性病例进行病毒基因型鉴定,以确定HCV基因型分布.

主要成果:

3,190名 (1.29%) 患者的抗HCV抗体检测结果呈阳性.
冠状病毒病毒1型 (52.2%) 和3型 (22.8%) 是最为普遍的.
观察到年龄,性别和HCV基因型分布之间的相关性.

结论:

肝炎C病毒基因型1和3在托斯卡纳东南部最为普遍.
了解基因型分布和人口相关性对于有针对性的HCV干预至关重要.
这些发现为该地区的HCV流行病学提供了洞察力,支持正在进行的控制工作.

关键词:

流行病学流行病学感染HCV的控制计划.肝炎C病毒感染者托斯卡纳地区的托斯卡纳.基因型基因型基因型

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